WASHINGTON (AP) — President Obama’s historic health care overhaul was thrown into uncertainty Monday by a federal judge’s decision to declare its central provision unconstitutional. Almost certainly headed to the Supreme Court, the issue hands ammunition to Republican opponents as they try to repeal the far-reaching law in the new Congress.

The ruling by U.S. District Judge Henry E. Hudson marked the first time that portions of the new law have been struck down. The decision follows earlier rulings by Democratic appointees in favor of the law.

Hudson declared that the law’s central requirement for nearly all Americans to carry insurance is unconstitutional, well beyond Congress’ power under the Constitution’s Commerce Clause or other provisions. He denied requests to strike down the law in its entirety or block it from being implemented while his ruling is appealed by the administration.

“An individual’s personal decision to purchase — or decline to purchase — health insurance from a private provider is beyond the historical reach of the Commerce Clause,” said Hudson, a 2002 appointee of President George W. Bush.

Nevertheless, the White House predicted it would prevail in the Supreme Court, although it may be a year or two before the health care law gets there. The next step for the Virginia lawsuit is the 4th U.S. Circuit Court of Appeals in Richmond, Va., where Democratic-appointed judges hold a majority.

But in the short term, the latest court ruling hands potent ammunition to GOP opponents as they prepare to assert control in the new Congress in January with promises to repeal the law.

Obama has promised to veto any repeal legislation and appears likely to be able to prevail since Democrats retain control of the Senate. Republicans also have discussed trying to starve the law of funding.

Hudson’s ruling may create uncertainty around the administration’s efforts to implement the landmark legislation extending health coverage to 32 million uninsured Americans. And it can only increase the public’s skepticism, which has not significantly receded in the months since the law’s enactment — defying Obama’s prediction that it would become more popular as the public got to know it.

Obama aides said implementation would not be affected, noting that the individual insurance requirement and other major portions of the legislation don’t take effect until 2014.

Underscoring the potential for Hudson’s ruling to become a political cudgel for the new Republican House majority, incoming House Speaker John Boehner, R-Ohio, quickly cautioned states against “investing time and resources in Obamacare’s implementation now that its central mandate has been ruled unconstitutional.”

“Republicans have made a pledge to America to repeal this job-killing health care law, and that’s what we’re going to do,” said Boehner. Calls to repeal the law were a staple of Tea Party campaign rallies this year.

White House officials sought to downplay the significance of the ruling, noting that two other federal judges have upheld the law as constitutional in recent months, and that other lawsuits are going forward. Arguments in a lawsuit by 20 states against the legislation gets under way Thursday in Florida. That suit also challenges whether the federal government can require states to expand their Medicaid programs.

“The bill will continue to have its day in court,” said White House press secretary Robert Gibbs.

“Challenges like this are nothing new in terms of laws that have come before the courts in the past in which our position has prevailed. We’re confident that it is constitutional.”

The lawsuit also gained a high profile because it was pursued by Virginia’s outspoken attorney general, Ken Cuccinelli. The two earlier cases decided in favor of the administration were brought by little-known legal entities.

In his ruling Hudson largely agreed with Cuccinelli’s argument that Congress exceeded its authority and dismissed the Justice Department’s argument that the requirement would come under the definition of regulating interstate commerce, a power given to Congress by the Constitution.

The mandate for people to buy insurance “is neither within the letter nor the spirit of the Constitution,” he said.

Hudson limited his ruling to striking down the so-called individual mandate, leaving intact other portions of the law — something supporters cast as a victory. But administration officials and outside analysts agree that important provisions of the legislation could not go forward without the requirement for everyone to be insured. That’s because insurers need to have large pools of healthy people, who are cheap to insure, or it is not financially tenable for them to extend coverage to anyone with a pre-existing condition or guarantee certain policies to nearly all comers.

Hudson recognized that his would not be the last word on the subject.

“The final word will undoubtedly reside with a higher court,” he wrote.

Several other lawsuits have been dismissed and still others are pending, including the one filed in Florida by 20 states.

White House health reform director Nancy-Ann DeParle said the administration is encouraged by the two other judges — in Virginia and Michigan — who have upheld the law. She said the Justice Department is reviewing Hudson’s ruling.